Ismail Lab

Publications

Publications

All University of Alberta publications from Dr. Ismail's PubMed record, with links to the full list.

Highlights from the lab are listed below. For the full publication record, see Dr. Ismail's profiles on PubMed and ResearchGate.

All publications on PubMed ResearchGate lab page

Recent publications

  1. 2025 · Sci Adv

    Pathogenic variants in MAEA disrupt DNA replication fork stability and are associated with developmental abnormalities in humans.

    Zeinali E, Mashayekhi F, Farraj RA, Hasanni T, et al.

    doi:10.1126/sciadv.adv0381

  2. 2024 · Cell Rep

    PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress.

    Mashayekhi F, Ganje C, Caron MC, Heyza JR, et al.

    doi:10.1016/j.celrep.2024.115066

  3. 2024 · J Biol Chem

    CDK-dependent phosphorylation regulates PNKP function in DNA replication.

    Mashayekhi F, Zeinali E, Ganje C, Fanta M, et al.

    doi:10.1016/j.jbc.2024.107880

  4. 2024 · J Biol Chem

    The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation.

    Locke AJ, Abou Farraj R, Tran C, Zeinali E, et al.

    doi:10.1016/j.jbc.2024.105709

  5. 2024 · Cell Oncol (Dordr)

    Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model.

    Mashhouri S, Rahmati A, Azimi A, Fava RA, et al.

    doi:10.1007/s13402-024-00950-w

  6. 2023 · Cells

    Unravelling the Role of PARP1 in Homeostasis and Tumorigenesis: Implications for Anti-Cancer Therapies and Overcoming Resistance.

    Lovsund T, Mashayekhi F, Fitieh A, Stafford J, Ismail IH.

    doi:10.3390/cells12141904

  7. 2023 · STAR Protoc

    Quantification of protein enrichment at site-specific DNA double-strand breaks by chromatin immunoprecipitation in cultured human cells.

    Sharma AK, Fitieh AM, Locke AJ, Ali JYH, Ismail IH.

    doi:10.1016/j.xpro.2022.101917

  8. 2022 · STAR Protoc

    Protocol to measure end resection intermediates at sequence-specific DNA double-strand breaks by quantitative polymerase chain reaction using ER-AsiSI U2OS cells.

    Sharma AK, Fitieh AM, Hafez Ali JY, Ismail IH.

    doi:10.1016/j.xpro.2022.101861

  9. 2022 · Int J Mol Sci

    The Role of DNA Repair in Genomic Instability of Multiple Myeloma.

    Ali JYH, Fitieh AM, Ismail IH.

    doi:10.3390/ijms23105688

  10. 2022 · Cell Rep

    BMI-1 regulates DNA end resection and homologous recombination repair.

    Fitieh A, Locke AJ, Mashayekhi F, Khaliqdina F, et al.

    doi:10.1016/j.celrep.2022.110536

  11. 2022 · Redox Biol

    Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents.

    Rashed FB, Diaz-Dussan D, Mashayekhi F, Macdonald D, et al.

    doi:10.1016/j.redox.2022.102300

  12. 2021 · Int J Mol Sci

    The Role of Polycomb Group Protein BMI1 in DNA Repair and Genomic Stability.

    Fitieh A, Locke AJ, Motamedi M, Ismail IH.

    doi:10.3390/ijms22062976

  13. 2021 · Nucleic Acids Res

    SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection.

    Locke AJ, Hossain L, McCrostie G, Ronato DA, et al.

    doi:10.1093/nar/gkaa1232

Selected earlier work

  1. 2016 · J Biol Chem

    RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.

    Hodge CD, Ismail IH, Edwards RA, Hura GL, et al.

    doi:10.1074/jbc.M116.715698

  2. 2016 · Cell Cycle

    BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair.

    Ismail IH, Dronyk A, Hu X, Hendzel MJ, Shaw AR.

    doi:10.1080/15384101.2015.1121322

  3. 2015 · Nat Cell Biol

    The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.

    Ismail IH, Gagné JP, Genois MM, Strickfaden H, et al.

    doi:10.1038/ncb3259

  4. 2014 · Cancer Res

    Germline mutations in BAP1 impair its function in DNA double-strand break repair.

    Ismail IH, Davidson R, Gagné JP, Xu ZZ, et al.

    doi:10.1158/0008-5472.CAN-13-3109

  5. 2013 · Cell Cycle

    Polycomb repressive complex 2 contributes to DNA double-strand break repair.

    Campbell S, Ismail IH, Young LC, Poirier GG, Hendzel MJ.

    doi:10.4161/cc.25795

  6. 2013 · J Biol Chem

    A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks.

    Ismail IH, McDonald D, Strickfaden H, Xu Z, Hendzel MJ.

    doi:10.1074/jbc.M113.461699

  7. 2012 · Nucleic Acids Res

    CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage.

    Ismail IH, Gagné JP, Caron MC, McDonald D, et al.

    doi:10.1093/nar/gks222

  8. 2010 · J Cell Biol

    BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair.

    Ismail IH, Andrin C, McDonald D, Hendzel MJ.

    doi:10.1083/jcb.201003034