Genome integrity, protein regulation, and precision oncology

We study how cancer cells exploit DNA repair to survive treatment and how to outmaneuver that resistance.

What we study

Our work sits at the intersection of DNA double-strand break repair, replication stress, and translational oncology in multiple myeloma and ovarian cancer.

Illustration of DNA break repair and replication fork protection

Theme 1

DNA repair & replication stress

Pathway choice between HR and NHEJ, ubiquitin and PARylation signalling, and how cells protect stalled replication forks.

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Illustration of cancer cell targeting and therapy biomarkers

Theme 2

Myeloma & ovarian cancer biology

Adaptive survival under chemotherapy-induced stress, combination strategies, and functional biomarkers for therapy response.

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Latest news

July 22, 2026: CIHR Operating Grant Awarded.
July 10, 2026: Meet a researcher: Ismail Ismail.
April 29, 2026: Outstanding Presentation by Rama!.

All news

Based at the Cross Cancer Institute

Department of Oncology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada.

About the lab